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ImageXpress HCS.ai rendszer

The ImageXpress® HCS.ai High-Content Screening System captures your imagination with high-quality imaging and analysis, enabling you to acquire the crystal-clear images and robust data you need with ease.

Powered by intuitive MetaXpress® Acquire software, the ImageXpress HCS.ai system integrates seamlessly with AI-driven IN Carta® Image Analysis Software for deep insights. An advanced, modular design offers the flexibility to perform a vast range of 2D and 3D assays in a single solution, while allowing for easy upgrades to meet evolving laboratory needs.

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Leírás

High-content imaging solution with proprietary spinning disc confocal

Modular and intuitive for optimal versatility

The ImageXpress HCS.ai system features a modular design and a wide array of customizable configuration options to meet your current needs and on-site upgrades to match your future requirements. The newly upgraded MetaXpress® Acquire software is an intuitive solution for users of all experience levels, providing direct access to reliable and insightful data.

Higher quality images and superior data analysis for deeper insights

Acquire high-quality images across a vast range of assay types, obtain exceptional image quality from your 3D samples, and unlock new discoveries with AI-powered IN Carta® Image Analysis Software.

Faster acquisition for accelerated high-throughput workflows

Boost lab productivity by imaging more plates in less time and simplifying the learning curve for new users. A new, automation friendly design enables you to integrate easily into automated workflows for faster, more reliable results.

Features

Multiple imaging modes

The system offers brightfield label-free imaging, widefield and confocal fluorescent imaging.

Automated water immersion objective technology option

Offers greater image resolution and sensitivity with up to 4x increase in signal, which leads to lower exposure times.

Streamlined upgrade pathway

The modular design enables additional capabilities to be easily added to your system, allowing easy upgrades as your needs evolve.

Exclusive AgileOptix™ spinning disk technology

Provides increased sensitivity with specially designed optics, high-powered laser illumination, and sCMOS sensor. Swappable disk geometries provide flexibility between speed and resolution.

High-intensity laser light source option

The option of laser illumination enables you to capture images faster with shorter exposure times and multiplex your experiments with 7 lasers and 8 imaging channels.

Magnification changer option

Get access to 12 magnifications within a single configuration, including high NA (Numerical Aperture) and ELWD (Extra-Long Working Distance) options.

MetaXpress® Acquire Software

The MetaXpress® Acquire acquisition package streamlines complex workflows—new users can get started quickly, whereas advanced users can leverage its flexibility to create optimized protocols.

AI-powered IN Carta® image analysis software

Leverages machine-learning to improve the accuracy and robustness of high-content image analysis, delivering data insights that other technologies miss. Reduces the complexity of image analysis with intuitive guided workflows in a modern user interface.

Műszaki specifikációk

Model	ImageXpress.HCS.ai Widefield	ImageXpress.HCS.ai Confocal	ImageXpress.HCS.ai Advanced
Widefield capability	Yes	Yes	Yes
Water immersion option (20X-60X)	Yes	Yes	Yes
Magnification changer option (1X and 1.5X)	Yes	Yes	Yes
Environmental control option	Yes	Yes	Yes
LED illumination	Yes	Yes
Standard spinning disk confocal (60μm pinhole (single), 60μm pinhole + 50μm slit (dual)		Yes	Yes
Deep tissue spinning disk 50μm pinhole Deep Tissue disk (dual)			Yes
Laser illumination			Yes

Applikációk

Applications of ImageXpress HCS.ai System

Organ-on-a-Chip Assays

Emulating organ physiology by co-culturing cells in a supportive 3D matrix and using microfluidic channels to perfuse nutrients or compounds over the resulting cellular structures, is rapidly gaining popularity as a biologically relevant screening model for new drugs or toxicity. The ImageXpress system provides a turnkey solution for both 2D or 3D applications and can accommodate many different types of slide and plate formats.
Neurite Outgrowth / Neurite Tracing

Neurons create connections via extensions of their cellular body called processes. This biological phenomenon is referred to as neurite outgrowth. Understanding the signaling mechanisms driving neurite outgrowth provides valuable insight into neurotoxic responses, compound screening, and for interpreting factors influencing neural regeneration. Using the ImageXpress Micro system in combination with MetaXpress Image Analysis Software automated neurite outgrowth imaging and analysis is possible for slide or microplate-based cellular assays.
Spheroid Assays

Three-dimensional (3D) cells cultured into spheroids provide a more complete and physiologically predictive model especially for cancer research. Acquiring measurements from the larger structure involves acquiring images from different depths within the body of the spheroid and analyzing them in 3D or collapsing into a single 2D stack before analysis. The ImageXpress Micro system and MetaXpress software are designed to make acquisition and analysis of 3D spheroids fast and accurate.
3D Cell Imaging and Analysis

Three-dimensional (3D) cell models are physiologically relevant and more closely represent tissue microenvironments, cell-to-cell interactions, and biological processes that occur in vivo. Now you can generate more predictive data by incorporating technologies like the ImageXpress system with the integrated 3D Analysis Module in MetaXpress software. This single interface will enable you to meet 3D acquisition and analysis challenges without compromise to throughput or data quality, giving you confidence in your discoveries.
3D Gel Matrix Assays

The development and integration of three-dimensional (3D) assay models are becoming popular to drive translational biology. Our ImageXpress system allows superior visualization of thick samples by minimizing background fluorescence and increasing sharpness, resulting in accurate image segmentation. Increase the biological relevance of your screening assays with a seamless integration between acquisition and analysis of cells in a 3D space to yield volume, intensity, and distance measurements.
Toxicity Screening

Screening for off-target or toxic effects is very important during the development of new drugs and for the extension of the therapeutic potential of existing molecules. ImageXpress systems are fully integrated hardware and software platforms for automated acquisition and analysis of images for high-throughput cell-based cytotoxicity testing. Configured with optional environmental control, living cell responses or kinetic reactions can be monitored in real time for several days.